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In these more info experiments, we noticed that prenatal BPA exposure led to a 37% reduction (P = 0.004) in EGFP+ neurons during the MeA of male EGFP+ mice when compared to Command mice (Fig. 3C). These success are per our conclusions in SH-SY5Y cells that show that BPA publicity results in a marked reduction during the cellular expression of aromatase.

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Replication with the Affiliation involving higher BPA concentrations and hypermethylation on the CYP19A1 brain promoter

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Mind aromatase, encoded by CYP19A1 and controlled through Mind promoter I.f6,7,eight converts neural androgens to neural estrogens9. During fetal enhancement, aromatase expression in the brain is high in males10 from the amygdala11,twelve. Notably, androgen disruption is implicated in the intense male brain principle for ASD13, and postmortem Examination of male ASD adults show markedly decreased aromatase activity in comparison to age-matched controls.

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